Home Lifestyle High-fat diet disturbs body clock, leads to overeating and obesity: Study |...

High-fat diet disturbs body clock, leads to overeating and obesity: Study | Health


A new study has found that when rats are fed a high-fat diet, this disturbs the body clock in their brain that normally controls satiety, leading to overeating and obesity.

The findings of the study were published in ‘The Journal of Physiology’.

The number of people with obesity has nearly tripled worldwide since 1975.

In England alone, 28 per cent of adults are obese and another 36 per cent are overweight.

Obesity can lead to several other diseases such as Type 2 diabetes, heart disease, stroke, and some types of cancer.

This new research may be a cornerstone for future clinical studies that could restore the proper functioning of the body clock in the brain, to avoid overeating.

Historically, it was believed that the master body clock was only located in a part of the brain called the hypothalamus.

However, further research over the years has clarified that some control of our body’s daily rhythms (hormone levels, appetite etc.) lies in several other parts of the brain and body, including a group of neurons in the evolutionary ancient brainstem, called the dorsal vagal complex (DVC).

Specifically, the DVC has been shown to control food intake by inducing satiety.

Research has also shown that in obesity, daily rhythms in food intake and the release of hormones related to eating, are blunted or eliminated.

However, it has not been clear if the malfunctioning of brain centres controlling appetite is a cause or the result of obesity.

This new research conducted at the Jagiellonian University in Krakow in collaboration with the University of Bristol found that high-fat diet-fed rats before they started to gain weight, showed changes in the DVC’s daily neuronal rhythms and the response of these neurons to appetite hormones.

Thus, the researchers propose that disturbance in the DVC’s timekeeping leads to obesity, rather than being the result of excessive body weight.

The research was performed on two groups of rats: those fed a well-balanced control diet (10 per cent kcal from fat) and a high-fat diet (70 per cent kcal from fat).

To mimic the impact of an unhealthy diet on humans, the researchers introduced the new diet to adolescent rats (4-week-old) and monitored their food intake across 24 hours for four consecutive weeks.

Electrophysiological recordings were performed to measure how DVC neuronal activity changes across 24h.

The use of multi-electrode arrays allowed for simultaneous monitoring of around a hundred DVC neurons from each brainstem slice.

This enabled the researchers to assess circadian changes of neuronal activity as well as neuronal responses to metabolically relevant hormones in each of the diet groups.

While the human and mouse brainstem share common features, the major limitation of the study for its immediate translation to humans is that it was performed on nocturnal animals (rats).

The peak of the DVC activity was observed at the end of the day, which is the rest phase for rodents, but an active phase for people. Thus, it remains to be established if the phase of the brainstem clock is set to day and night, or whether it depends on patterns of rest and activity.

This study opens new research opportunities for trying to establish the strategy how to restore body clock function of the DVC and therefore help tackle obesity.

Dr Lukasz Chrobok, the first author of the study said, “I’m really excited about this research because of the possibilities it opens up to tackle the growing health issue of obesity. We still do not know what are the time cues which are able to reset or synchronise the brainstem clock.”

Dr Chrobok concluded, “Hopefully, the restoration of daily rhythms in this satiety centre before or after the onset of obesity may provide new therapeutic opportunities.” 

Follow more stories on Facebook and Twitter

This story has been published from a wire agency feed without modifications to the text. Only the headline has been changed.





Source link

RELATED ARTICLES

Loved Ananya Panday’s glam three-piece bikini in Maldives holiday pics? Here’s what it costs | Fashion Trends

Bollywood star Ananya Panday served major wanderlust vibes on the weekend as she escaped to the Maldives for a mini holiday. Taking to...

UP issues guidelines for Navratri, Dussehra and Chehallum. Details here | Latest News India

The guidelines issued by Yogi Adityanath government in Uttar Pradesh say that small vehicles should be used for the immersion of idols and...

Better sleep pattern can boost teens’ ability to cope with pandemic? Here’s what study says | Health

According to the researchers, encouraging better sleeping habits could help reduce teens' stress and improve their ability to cope in times of crisis.The...

LEAVE A REPLY

Please enter your comment!
Please enter your name here

Most Popular

Charanjit Channi's Oath As Punjab Chief Minister Today, Rahul Gandhi To Attend

Rahul Gandhi to attend Charanjit Singh Channi's oath as Punjab Chief Minister today Source link

Britain’s Boris Johnson Cautious Over Fulflling UN Climate Pledges

<!-- -->Boris Johnson will convene meeting of leaders along with UN Secretary-General Antonio Guterres.London: Forcing wealthy nations to honour their UN climate fund...

Chris Cairns, New Zealand Cricket Great, Faces “Greatest Challenge”

Chris Cairns shared a video in which he thanked the surgeons, doctors, nurses who "saved my life".© TwitterNew Zealand cricket great Chris Cairns...

Exams Alone Don’t Make Life

<!-- -->Actor Suriya Sivakumar made an emotional appeal to students to not end their lives.Chennai: Actor Suriya Sivakumar has reached out to students...

Recent Comments