Home Latest Stories Scientists Identify Drug Targets For Pan-Coronavirus Treatment

Scientists Identify Drug Targets For Pan-Coronavirus Treatment


Scientists Identify Drug Targets For Pan-Coronavirus Treatment

The study identified highly conserved sequences that could make the best drug targets. (Representational)

Toronto:

Scientists have identified the most highly conserved drug-binding pockets in viral proteins from COVID-19 patient samples and from other coronaviruses, revealing the most promising targets for pan-coronavirus drugs.

The researchers from the University of Toronto in Canada noted that safe and effective vaccines offer hope for an end to the COVID-19 pandemic.

However, the possible emergence of vaccine-resistant SARS-CoV-2 variants, as well as novel coronaviruses, make finding treatments that work against all coronaviruses as important as ever, they said.

The study, published in the Journal of Proteome Research, analysed viral proteins across 27 coronavirus species and thousands of samples from COVID-19 patients.

It identified highly conserved sequences that could make the best drug targets.

Drugs often bind inside “pockets” on proteins that hold the drug snugly, causing it to interfere with the protein’s function.

Scientists can identify potential drug-binding pockets from the three dimensional (3D) structures of viral proteins.

However, over time, viruses can mutate their protein pockets so that drugs no longer fit.

The researchers noted that some drug-binding pockets are so essential to the protein’s function that they cannot be mutated, and these sequences are generally conserved over time in the same and related viruses.

They used a computer algorithm to identify drug-binding pockets in the 3D structures of 15 SARS-CoV-2 proteins.

The team found corresponding proteins in 27 coronavirus species and compared their sequences in the drug-binding pockets.

The two most conserved druggable sites were a pocket overlapping the RNA binding site of the helicase nsp13, and a binding pocket containing the catalytic site of the RNA-dependent RNA polymerase nsp12.

Both of these proteins are involved in viral RNA replication and transcription.

The drug-binding pocket on nsp13 was also the most highly conserved across thousands of SARS-CoV-2 samples taken from COVID-19 patients, with not a single mutation.

The researchers noted that novel antiviral drugs targeting the catalytic site of nsp12 are currently in phase II and III clinical trials for COVID-19.

The RNA binding site of nsp13 is a previously underexplored target that should be a high priority for drug development, they added.

(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.)



Source link

RELATED ARTICLES

France’s Macron Not Ready To Calm Down After Submarine Humiliation

<!-- -->French president Macron recalled ambassadors to Washington and Canberra and canceled events.Emmanuel Macron is making it clear that French fury isn't ebbing...

Heavy Rain In Kolkata, Adjoining Areas

<!-- -->Kolkata: The rainfall is likely to continue for the next two to three hours.Kolkata: In view of the movement of cyclonic circulation...

Nearly 81 Crore Covid Vaccine Doses Administered In India So Far

<!-- -->Covid Vaccine Doses: India recorded 30,256 new COVID-19 cases in the last 24 hours. (File)New Delhi: India has administered over 80.85 crore...

LEAVE A REPLY

Please enter your comment!
Please enter your name here

Most Popular

France’s Macron Not Ready To Calm Down After Submarine Humiliation

<!-- -->French president Macron recalled ambassadors to Washington and Canberra and canceled events.Emmanuel Macron is making it clear that French fury isn't ebbing...

IPL 2021, CSK vs MI: Ruturaj Gaikwad Reveals How He Planned CSK Revival Against MI After Top Order Collapse

CSK's Ruturaj Gaikwad in action in the IPL.© BCCI/IPLAfter playing a match-winning knock of 88 runs against Mumbai Indians, Chennai Super Kings (CSK)...

Weight Loss Attempts Not Working as Desired? Time to Pay Attention to Your Gut Microbiome, Study Suggests

COVID-19 pandemic and its subsequent stay-at-home scenario forced people to renew focus on themselves and choose healthy options over a sedentary lifestyle. Some...

Shilpa Shetty starts packed Monday morning with Setuasana, read all its benefits | Health

When it comes to strengthening the body, relaxing the muscles, achieving peace, and nailing fitness goals, Bollywood actor Shilpa Shetty always swears by...

Recent Comments